Glasgow Morning Lectures
All Members and Guests Including Retired Members Are Welcome to Attend
Venue: Seminar Room, The Gilchrist Post Graduate Club, University of Glasgow
Date: Wednesday 22 January 2020
Time: 10.00 to 12.30 (approx.)
Lectures will be given by: Dr William Sandham, Founder and Managing Director of Scotsig and Prof Rob Mairs, Glasgow University (title and abstracts at end).
There is no cost for attending the lectures.
Please email Gail Millar at the following email address by Friday 10 January if you would like to attend the lectures, stating the number of people attending.
After the lectures the speakers will be going for lunch at “Stravaigin" in Gibson Street which is a 5 minute walk from the university.
Website for the restaurant is https://www.stravaigin.co.uk/
If you wish to attend the lunch then you must make your own booking.
Information On Lectures
Dr William Sandham
Signal and Image Processing: An Extraordinary Enabling Technology by William A. Sandham B.Sc. (Glasgow), Ph.D. (Birmingham), FIET, SMIEEE, MEAEG, MSEG
Professor Sandham is Founder and Managing Director of Scotsig, an independent signal and image processing research, consultancy and training company, based in Glasgow, Scotland. He is also visiting Professor in the Department of Electronics, University of Javeriana, Bogotá, Colombia, and Department of Biomedical Engineering, University of Strathclyde, Glasgow.
Much of the success of modern technology we now enjoy in our everyday professional and social lives, owes a great deal to the discipline of signal and image processing or SIP. This discipline has a very long and distinguished record of innovation and achievement in many diverse and challenging application domains, including radar, communications, biomedical engineering, geophysics, and increasingly in our many leisure pursuits. This talk will review the fundamental principles of SIP, both analogue and digital, and also some principal SIP applications.
Prof Rob Mairs
Bystander effects induced by targeted radionuclides by Professor Rob Mairs D.Sc.
Professor Mairs is Group Head and Professor of Experimental Radiation Oncology at the Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow.
Radiation as a cancer modality is of high physical precision but limited biological specificity. Targeted radiotherapy, the delivery of radiation to cancer cells by radionuclides conjugated to tumour-seeking agents, is a biologically attractive option.
The radiopharmaceutical [131I] meta-iodobenzylguanidine ([131I] MIBG) is an effective single agent for the treatment of neuroblastoma. However, uptake of the drug in malignant sites is insufficient to cure advanced stage disease.
Non-uniform distribution of radiopharmaceuticals in tumours is a major constraint upon the efficacy of targeted radionuclide therapy. It may be possible to compensate for heterogeneity of uptake of [131I] MIBG, resulting in underdosing of some tumour regions, by exploiting radiation-induced biological bystander effects deriving from the cellular processing of the physical radiation insult. This phenomenon may play an important part in the overall efficacy of radionuclide targeting.
We examined this effect using media transfer methodology. Medium from cells that accumulated radiopharmaceutical was transferred to cells which had not been exposed to radioactivity and clonogenic survival was determined in donor and recipient cultures. We observed that potent toxins were generated specifically by cells which concentrated radiohalogenated MIBG. These were LET-dependent and distinct from those elicited by conventional radiotherapy. Recently we have been characterising the nature of radionuclide-induced bystander signals and determining the dependence upon genotype (e.g.P53 status) of the efficiency of this mode of kill in tumour cells.
Elucidation of the pathways involved in the generation of factors by radionuclide-concentrating tumour cells could indicate ways of manipulating bystander signal production to reduce toxicity to normal tissues that may be inadvertently irradiated during the course of a targeted radiotherapy regime. With the growing appreciation of the significance of radiation-induced bystander effects, it is becoming clear that these must be rigorously studied with respect to their chemical nature, tumour specificity, and dose- and time-dependence.
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